Result: During cap stage and early bell stage, the expression of MMP-20 mRNA was negative in enamel organ, dental papilla and dental sac and that of TIMP-1 mRNA could be observed in dental papilla; 结果:帽状期及钟状早期,成釉器、牙乳头及牙囊MMP-20mRNA表达阴性;TIMP-1mRNA在牙乳头表达;
Results: bmp3 was found in dental sac surrounding the germs at the early stage of tooth root development, and in cementoblasts and periodontal cells at the later stage. 结果:bmp3的表达始于牙根发育早期的牙囊组织,之后转移到成牙骨质细胞和牙周膜细胞中;
Otherwise it was absent in normal dental sac or remnant dental lamina epithelia. FGFR3在正常牙囊或残余牙板上皮中呈阴性表达。
BMP may also be found in human tooth germs, predentin, the cells of outer and inner enamel epithelium, and the cells of dental sac generating alveolar bone. 在人的牙胚中,BMP主要分布在前期牙木质、外釉细胞和造釉细胞以及形成牙槽骨的牙囊细胞中,表明骨的生长和形成以及牙齿的发育都与BMR密切相关。